Iron–Sulfur Clusters toward Stresses: Implication for Understanding and Fighting Tuberculosis
نویسندگان
چکیده
Tuberculosis (TB) remains the leading cause of death due to a single pathogen, accounting for 1.5 million deaths annually on global level. Mycobacterium tuberculosis, causative agent TB, is persistently exposed stresses such as reactive oxygen species (ROS), nitrogen (RNS), acidic conditions, starvation, and hypoxic all contributing toward inhibiting bacterial proliferation survival. Iron–sulfur (Fe-S) clusters, which are among most ancient protein prosthetic groups, good targets ROS RNS, susceptible Fe starvation. Mtb holds Fe-S containing proteins involved in essential biological process Mtb. cluster assembly achieved via complex machineries. Many organisms contain several systems, while SUF system only one some pathogens The essentiality machinery its functionality under stress conditions encountered by underlines how it constitutes an attractive target development novel anti-TB.
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ژورنال
عنوان ژورنال: Inorganics (Basel)
سال: 2022
ISSN: ['2304-6740']
DOI: https://doi.org/10.3390/inorganics10100174